Chiropractic Research, Wellness and Alternative Medicine Overview
Authors: Li G, Li J, Zhou Q, Song X, Liang H, Huang L
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are the most common complications of sepsis, and the mortality of sepsis-induced ALI remains high in critically ill patients. Growth hormone releasing peptide-2 (GHRP-2), a ghrelin agonist, has been shown to exert beneficial effects on various inflammatory diseases. We therefore explored whether GHRP-2 possesses anti-inflammatory properties in the pathogenesis of lipopolysaccharide (LPS)-induced ALI. Male Sprague-Dawley rats were intratracheally instilled with LPS (2 mg/kg) to induce ALI. ALI was confirmed with lung tissue injury (histopathological examination), enhanced lung edema (wet-to-dry weight ratio), and neutrophil infiltration (myeloper...
The Tohoku Journal of Experimental Medicine
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September 2, 2010
Authors: Toda K, Harada T
Parkinson's disease (PD) is characterized by resting tremor, slow and decreased movement (hypokinesia and akinesia), rigidity, postural instability, problems with gait, and coordination. The prevalence of PD is between 0.1% and 0.3% in the general population and between 1% and 2% in persons 65 years of age or older. Patients with PD are more likely to suffer from pain. Indeed, the chief complaint of patients with severe motor disturbance and severe pain is pain rather than motor disturbance. Fibromyalgia (FM) is defined by widespread pain (pain in the left and right sides of the body, pain above the waist, pain below the waist, and axial skeletal pain) for more than 3 months and the presence of at least 11 of the 18 specified tender points. FM and chronic wide...
The Tohoku Journal of Experimental Medicine
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September 2, 2010
The treatment of patients with early-stage non-small cell lung cancer and cardiopulmonary dysfunction has rapidly evolved during the past decade. Although fractionated radiotherapy has been the most frequently used alternative treatment, additional approaches, including limited resection with or without brachytherapy, stereotactic body radiotherapy, and radiofrequency ablation are increasingly used and have now been studied prospectively. This review will focus on the potential current role of fractionated radiotherapy for high-risk patients with particular consideration of altered fractionation schemes and recent advances in treatment related technology. (Source: Seminars in Thoracic and Cardiovascular Surgery)
Seminars in Thoracic and Cardiovascular Surgery
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September 2, 2010
This article reviews the history of SRS as applied to lung tumors, summarizes the currently available data on efficacy and toxicity, and describes some of the current controversial aspects of this treatment. (Source: Seminars in Thoracic and Cardiovascular Surgery)
Seminars in Thoracic and Cardiovascular Surgery
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September 2, 2010
Abstract.â (Source: Journal of Internal Medicine)
Journal of Internal Medicine
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September 2, 2010
(Source: Journal of Internal Medicine)
Journal of Internal Medicine
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September 2, 2010
Abstract.â (Source: Journal of Internal Medicine)
Journal of Internal Medicine
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September 2, 2010
Abstract.â (Source: Journal of Internal Medicine)
Journal of Internal Medicine
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September 2, 2010
Abstract.â (Source: Journal of Internal Medicine)
Journal of Internal Medicine
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September 2, 2010
Abstract.â (Source: Journal of Internal Medicine)
Journal of Internal Medicine
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September 2, 2010
(Source: Journal of Internal Medicine)
Journal of Internal Medicine
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September 2, 2010
Abstract.â (Source: Journal of Internal Medicine)
Journal of Internal Medicine
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September 2, 2010
Abstract.â (Source: Journal of Internal Medicine)
Journal of Internal Medicine
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September 2, 2010
(Source: Journal of Internal Medicine)
Journal of Internal Medicine
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September 2, 2010
(Source: Journal of Internal Medicine)
Journal of Internal Medicine
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September 2, 2010
(Source: Journal of Internal Medicine)
Journal of Internal Medicine
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September 2, 2010
Abstract: Background: Juvenile breast hypertrophy is uncommon and is characterized by excessive breast enlargement in the peripubertal period. The clinical entity is thought to result from increased sensitivity of mammary tissue to normal levels of circulating hormones.Case: Here, we report a female patient, aged 12 years and 6 months, suffering from juvenile breast hypertrophy, who presented at the third month of symptoms and benefited from tamoxifen treatment.Comments: In experienced clinics, use of tamoxifen in the treatment of juvenile breast hypertrophy during the brisk growth period may become a medical alternative to reconstructive surgery. (Source: Journal of Pediatric and Adolescent Gynecology)
Journal of Pediatric and Adolescent Gynecology
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September 2, 2010
(Source: International Journal of Mental Health Nursing)
International Journal of Mental Health Nursing
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September 2, 2010
Nature Reviews Drug Discovery 9, 680 (2010). doi:10.1038/nrd3261
Author: Charlotte Harrison
The fungal pathogen Candida albicans causes serious infections in immunocompromised individuals, and although treatment is possible using azole or echinocandin drugs, their efficacy can be compromised by the emergence of drug-resistant strains. Writing in Nature Medicine, Wurtele and colleagues show that fungal enzymes (Source: Nature Reviews Drug Discovery)
Nature Reviews Drug Discovery
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September 1, 2010
In the recent paper by Tachjian et al. (), the investigators highlight several important points concerning the use of herbal supplements: 1) their use is widespread, especially among certain important subgroups, such as patients taking prescription medications; 2) disclosure of complementary and alternative medicine use by patients to their physicians remains low; and 3) potentially dangerous herb-drug interactions may be missed. I applaud the investigators for undertaking a topic that is important not only for patients with cardiovascular diseases but also for those with cancer and other chronic diseases. However, a variety of shortcomings in their methods and conclusions detract from the overall importance of their message. (Source: Journal of the American College of Cardiology)
Journal of the American College of Cardiology
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September 1, 2010
Abstract Over the past 20 years, the center of pressure (COP) has been commonly used as an index of postural stability in standing.
While many studies investigated COP excursions in low back pain patients and healthy individuals, no comprehensive analysis
of the reported differences in postural sway pattern exists. Six online databases were systematically searched followed by
a manual search of the retrieved papers. The selection criteria comprised papers comparing COP measures derived from bipedal
static task conditions on a force-plate of non-specific low back pain (NSLBP) sufferers to those of healthy controls. Sixteen
papers met the inclusion criteria. Heterogeneity in study designs prevented pooling of the data so only a qualitative data
analysis was conducted. T...
European Spine Journal
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August 18, 2010
An Austin investor-backed chiropractic franchise will expand to 1,500 locations within the next 10 years, officials said in a press release Tuesday. (Source: bizjournals.com Health Care:Health Insurance headlines)
bizjournals.com Health Care:Health Insurance headlines
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August 17, 2010
An Austin investor-backed chiropractic franchise will expand to 1,500 locations within the next 10 years, officials said in a press release Tuesday. (Source: bizjournals.com Health Care:Biotechnology headlines)
bizjournals.com Health Care:Biotechnology headlines
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August 17, 2010
Conclusion: The care provided to this patient seemed to help resolve his chronic musculoskeletal dysfunction and pain and improve his academic performance. (Source: Journal of Chiropractic Medicine)
Journal of Chiropractic Medicine
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August 16, 2010
Abstract: Several primary studies have shown that an anatomical short leg predicts anterior rotation of the ipsilateral ilium, whereas anatomical long leg predicts posterior rotation of the ilium on the long leg side. At the same time, in chiropractic and other manual therapy professions, it is widely believed that the leg check finding of a short leg is associated with posterior ilium rotation, and a long leg with anterior ilium rotation. The purpose of this commentary is to explore the consequences of this paradox for the manual therapy professions, insofar as leg checking procedures are commonly used to derive appropriate vectors for chiropractic manipulation/adjustive procedures. (Source: Journal of Chiropractic Medicine)
Journal of Chiropractic Medicine
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August 16, 2010
(Source: Journal of Chiropractic Medicine)
Journal of Chiropractic Medicine
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August 16, 2010
(Source: Journal of Chiropractic Medicine)
Journal of Chiropractic Medicine
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August 16, 2010
(Source: Journal of Chiropractic Medicine)
Journal of Chiropractic Medicine
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August 16, 2010
(Source: Journal of Chiropractic Medicine)
Journal of Chiropractic Medicine
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August 16, 2010
(Source: Journal of Chiropractic Medicine)
Journal of Chiropractic Medicine
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August 16, 2010
(Source: Journal of Chiropractic Medicine)
Journal of Chiropractic Medicine
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August 16, 2010
Conclusion: Some studies have noted improvement in insomnia following manual therapy; however, based on clinical trials, there is minimal evidence of support for chiropractic in insomnia. Further studies with high methodological scores need to be conducted. (Source: Journal of Chiropractic Medicine)
Journal of Chiropractic Medicine
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August 16, 2010
Conclusion: Lipomas are common benign soft tissue masses and should be considered in the differential diagnosis of a thigh mass. Magnetic resonance imaging with contrast depicts the lipomatous mass as having a characteristic high-intensity fat signal without enhancement. It is important for clinicians to have an increased awareness in recognizing the clinical and imaging manifestations of a soft tissue lipoma to optimize an initial diagnosis and treatment. (Source: Journal of Chiropractic Medicine)
Journal of Chiropractic Medicine
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August 16, 2010
Conclusion: These findings suggest that BTX-A may be a therapeutic option for the treatment of bruxism and related disorders. (Source: Journal of Chiropractic Medicine)
Journal of Chiropractic Medicine
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August 16, 2010
Conclusion: When each examiner was âvery confidentâ as to the most fixated thoracic segment, the levels they identified were very close. This corresponds to âgoodâ agreement, an uncommon result in most interexaminer motion palpation studies. Thus, the confidence level of examiners had an effect on the interexaminer reliability of thoracic spine. Our novel continuous measures, statistical methodology, and subtyping the subjects according to the confidence of the palpators seem more capable than level-by-level discrete analysis of detecting interexaminer agreement. (Source: Journal of Chiropractic Medicine)
Journal of Chiropractic Medicine
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August 16, 2010
Conclusion: A total of 9 chiropractic lower back manipulations caused the mediators of inflammation to present a normalization response in individuals suffering from chronic low back pain. (Source: Journal of Chiropractic Medicine)
Journal of Chiropractic Medicine
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August 16, 2010
Conclusion: It is considered that knowledge of these little-known pyramidal fields of the medial wall of the human brain is essential to the understanding of how the brain functions both in sickness and in health. (Source: Journal of Chiropractic Medicine)
Journal of Chiropractic Medicine
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August 16, 2010
Acupuncture was first legalized in Maryland in 1973. By the end of 2009, regulatory legislation had passed in all but six states. The growth of acupuncture is most commonly measured by its well-documented demand as a treatment modality and the rapid increase in the number of licensees. Much less documented is a puzzling stagnation in work opportunities and income. As many as half of all licensees, on graduation and licensure, may be unable to support themselves by working in their chosen profession. However, unlike other well-established complementary and alternative health professions, such as chiropractic and massage, acupuncture is conspicuously absent from the Bureau of Labor and Statistics occupations manual, with only a handful of secondary and incomplete studies available, which tog...
Complementary Health Practice Review
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August 12, 2010
There is a place for the acupuncture profession within primary care. Nationwide, community clinics that serve the population of under- and uninsured persons are facing a tremendous shortage of primary care practitioners. Marginalized health care professions, that is, acupuncture, chiropractic, and naturopathy, are being drawn into a primary care role. An unanticipated workforce opportunity exists to fill the caregiver gap in community clinics. This transition can be quickly realized in states such as California where statutory code states that acupuncture is to be regulated and controlled as a primary care profession, but the requisite training has yet to be provided. Specific clinical experience in primary care settings would help overcome long-standing barriers that have resulted in the ...
Complementary Health Practice Review
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August 12, 2010
Conclusions:
Available evidence supports the hypothesis that the attrition rate for licensed chiropractors in the first 10 years of practice has risen in the past several decades. (Source: Chiropractic and Osteopathy)
Chiropractic and Osteopathy
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August 11, 2010
Abstract (Source: Acta Paediatrica)
Acta Paediatrica
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September 2, 2010
In conclusion, dietary soy isoflavones are neuroprotective in transient focal cerebral ischemia in male and OVX female rats. These isoflavones may protect the brain via increases in endogenous antioxidant mechanisms and reduced oxidative stress. (Source: AJP: Regulatory, Integrative and Comparative Physiology)
AJP: Regulatory, Integrative and Comparative Physiology
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September 1, 2010
Male sex is associated with higher blood pressure and greater renal injury, perhaps related to greater sensitivity to ANG II. In anesthetized male and female C57BLK/6 mice, we assessed responses of mean arterial pressure (MAP) and renal vascular resistance (RVR; Transonic flow probe) to acute bolus injections of ANG II (0.3–3.0 µg/kg iv) and phenylephrine (PE; 30–300 µg/kg) during low-, normal-, and high-sodium diets. The role of reactive oxygen species was determined by coadministration of tempol. ANG II type 1 and type 2 (AT1 and AT2) receptor and endothelial nitric oxide synthase (NOS3) expression were determined in dissected kidney vessels. While no difference was found on the low-sodium (LS) diet, MAP and RVR responses to ANG II were greater in males during the...
AJP: Regulatory, Integrative and Comparative Physiology
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September 1, 2010
Dietary methionine restriction (MR) limits fat deposition and decreases plasma leptin, while increasing food consumption, total energy expenditure (EE), plasma adiponectin, and expression of uncoupling protein 1 (UCP1) in brown and white adipose tissue (BAT and WAT). β-adrenergic receptors (β-AR) serve as conduits for sympathetic input to adipose tissue, but their role in mediating the effects of MR on energy homeostasis is unclear. Energy intake, weight, and adiposity were modestly higher in β3-AR–/– mice on the Control diet compared with wild-type (WT) mice, but the hyperphagic response to the MR diet and the reduction in fat deposition did not differ between the genotypes. The absence of β3-ARs also did not diminish the ability of MR to increase total EE ...
AJP: Regulatory, Integrative and Comparative Physiology
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September 1, 2010
CONCLUSIONS:
Higher intake of fish, EPA, and DHA was independently associated with a lower prevalence of depressive symptoms in early male, but not female, adolescents. (Source: PEDIATRICS)
PEDIATRICS
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September 1, 2010
Conclusion: Quantitative measures of macronutrient intake in adolescents were associated with objectively measured sleep duration. Short sleep duration may increase obesity risk by causing small changes in eating patterns that cumulatively alter energy balance.
Keywords: Sleep duration, diet, obesity, adolescents, 24-hour food recall (Source: Sleep)
Sleep
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September 1, 2010
The Cry1Ia12 entomotoxin from a Brazilian Bacillus thuringiensis strain is currently being expressed in cotton cultivars to confer resistance to insect-pests. The present study aimed to assess the effects of a diet containing Cry1Ia12 protein on growing rats. A test diet containing egg white and Cry1Ia12 (0.1% of total protein) as a protein source was offered to rats for ten days. In addition, an acute toxicity bioassay was performed in rats with a single oral dose of the entomotoxin (12 mg/animal). No adverse effects were observed in the animals receiving the test diet when compared to those receiving a control diet (egg white). The analysed parameters included relative dry weight of internal organs, duodenum histology, blood biochemistry, and nutritional parameters. The results of th...
Journal of Biomedicine and Biotechnology
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September 1, 2010
This study examines whether there is an incremental effect on blood pressure control when using a nurse clinic combined with telephone follow-up.Methods: This was a randomised controlled trial. The primary outcome measure was blood pressure reading. The secondary outcome measures included adherence to home blood pressure monitoring, exercise, diet, medication, and satisfaction with care.Results: There were no significant differences in the baseline measures between the control and study groups. Significant differences were found at 8 weeks after intervention was initiated between groups in, systolic blood pressure (control â7.97 vs study â19.03, t=2.35, p=0.022, CI 1.66â20.47) and diastolic, blood pressure (control â3.72 vs study â11.68, t=3.02, p=0.004, CI 2.68â13.24). Other v...
International Journal of Nursing Studies
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September 1, 2010
Conclusions: Male and female patients with MDD and BD exhibit selective erythrocyte DHA deficits relative to healthy controls, and this deficit was numerically greater in BD patients. Selective DHA deficits are consistent with impaired peroxisome function, which has implications for n-3 fatty acid interventions aimed at preventing or reversing this deficit. (Source: Journal of Affective Disorders)
Journal of Affective Disorders
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September 1, 2010
Authors: M Salmenhaara, L Uusitalo, U Uusitalo, C Kronberg-Kippilä, H Sinkko, S Ahonen, R Veijola, M Knip, M Kaila
& S M Virtanen (Source: European Journal of Clinical Nutrition)
European Journal of Clinical Nutrition
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August 31, 2010
Authors: M Camões, A Oliveira, M Pereira, M Severo
& C Lopes (Source: European Journal of Clinical Nutrition)
European Journal of Clinical Nutrition
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August 31, 2010
Development of a lifestyle–diet quality index for primary schoolchildren and its relation to insulin resistance: the Healthy Lifestyle–Diet Index
European Journal of Clinical Nutrition advance online publication, September 1, 2010. doi:10.1038/ejcn.2010.172
Authors: Y Manios, G Kourlaba, E Grammatikaki, A Koubitski, P-E Siatitsa, A Vandorou, K Kyriakou, V Dede
& G Moschonis (Source: European Journal of Clinical Nutrition)
European Journal of Clinical Nutrition
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August 31, 2010
Authors: L E Thornton, D A Crawford
& K Ball (Source: European Journal of Clinical Nutrition)
European Journal of Clinical Nutrition
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August 31, 2010
In conclusion, our studies demonstrated the promise of combinations of PEITC-NAC, I3C/DIM and MI for the chemoprevention of lung carcinogenesis in current and former smokers. (Source: Carcinogenesis)
Carcinogenesis
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August 31, 2010
Conjugated linoleic acid (CLA) is a class of commercially available fatty acids that have been associated with anticancer properties in rodent models of chemical carcinogenesis. We conducted a pilot study to examine the antitumor effect of dietary CLA in a polyoma virus-middle T antigen (PyMT) mouse model of invasive breast cancer. Virgin 4-week-old PyMT mice were administered a mixed-isomer CLA diet (1% wt/wt) or control AIN-93G diet for 4 weeks (N = 6 and 5, respectively) and tumor burden was assessed at 8 weeks of age. Thoracic mammary glands were prepared as whole mounts with other glands being formalin fixed and paraffin embedded for histology and immunohistochemistry (IHC). Total RNA was prepared for microarray and real-time reverse transcription–polymerase chain reaction analy...
Carcinogenesis
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August 31, 2010
Docosahexaenoic acid (DHA), a 22:6 n-3 polyunsaturated fatty acid, is the longest and most highly unsaturated fatty acid found in most membranes and has been shown to inhibit cancer cell growth in part by modifying cell signaling. In the current study, alterations to epidermal growth factor receptor (EGFR) signaling upon DHA supplementation are examined in A549 lung adenocarcinoma, WiDr colon carcinoma and MDA-MB-231 breast carcinoma cell lines. Interestingly, EGFR phosphorylation, most notably at the tyrosine 1068 residue, is dramatically upregulated, and EGFR association with the Sos1 guanine nucleotide exchange factor is concomitantly increased upon DHA supplementation. However, guanosine triphosphate-bound Ras and phosphorylated extracellular signal-regulated kinase (Erk)1/2 are parado...
Carcinogenesis
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August 31, 2010
Purpose of review: The exploding prevalence of insulin resistance and Type 2 diabetes (T2D) linked to obesity has become an alarming public health concern. Worldwide, approximately 171 million people suffer from obesity-induced diabetes and public health authorities expect this situation to deteriorate rapidly. An interesting clinical population of 'metabolically healthy but obese' (MHO) cases is relatively protected from T2D and its associated cardiovascular risk. The molecular basis for this protection is not well understood but is likely to involve reduced inflammatory responses. The inflammatory cells and pathways that respond to overnutrition are the primary subject matter for this review.
Recent findings: The chance discovery of a genetic mutation in the Brd2 gene, which is located ...
Current Opinion in Endocrinology, Diabetes and Obesity
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August 30, 2010
Conclusion:
Regulatory systems involved in the pregnancy-induced plasma volume expansion are susceptible to the effects of maternal protein restriction. (Source: Reproductive Biology and Endocrinology)
Reproductive Biology and Endocrinology
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August 30, 2010
Although obesity-related cardiovascular disease and hypoxia are associated with erectile dysfunction, little is known about the direct effects of hypoxia on penile arteries. In the present study, the effects of acute hypoxia (Po2 = ~10 Torr, 20 min) were investigated in isolated penile arteries to determine the influence of endothelium removal, nitric oxide (NO) synthase (NOS), cyclooxygenase (COX), NADPH oxidase, changes in reactive oxygen species (ROS), and a high-fat diet. Hypoxia-relaxed penile arteries contracted with phenylephrine by ~50%. Relaxation to hypoxia and acetylcholine was reduced by endothelium removal and by inhibition of NOS (N-nitro-l-arginine) and COX (indomethacin) but was enhanced by Tempol and by NADPH oxidase inhibition with apocynin and gp91ds-tat. Basal superoxid...
AJP: Heart and Circulatory Physiology
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August 30, 2010
Recent work has made it clear that oxidant systems interact. To investigate potential cross talk between NADPH oxidase (Nox) 1 upregulation in vascular smooth muscle and endothelial function, transgenic mice overexpressing Nox1 in smooth muscle cells (TgSMCnox1) were subjected to angiotensin II (ANG II)-induced hypertension. As expected, NADPH-dependent superoxide generation was increased in aortas from Nox1-overexpressing mice. Infusion of ANG II (0.7 mg·kg–1·day–1) for 2 wk potentiated NADPH-dependent superoxide generation and hydrogen peroxide production compared with similarly treated negative littermate controls. Endothelium-dependent relaxation was impaired in transgenic mice, and bioavailable nitric oxide was markedly decreased. To test the hypothesis that ...
AJP: Heart and Circulatory Physiology
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August 30, 2010
This article describes veterans with service-connected disability for major lower- and/or upper-limb loss resulting from combat-field-associated injuries sustained in the Vietnam war, Operation Desert Shield/Operation Desert Storm, and Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF). Using the Department of Veterans Affairs (VA) Compensation and Pension Mini-Master file, we identified 2,690 veterans who in August 2007 received compensation for loss of one or more limbs. More than 97% sustained their injuries in Vietnam; most were young men who served in the U.S. Army or Marine Corps. All but 5% had at least 50% combined service-connected disability and nearly half had a 100% rating. In addition to limb loss, one of the most prevalent compensable conditions was posttraumatic st...
J Rehabil Res Dev
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September 2, 2010
This study projects prosthetic- and assistive-device costs for veterans with limb loss from Vietnam and injured servicemembers returning from Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF) to inform the Department of Veterans Affairs (VA) for these veterans' future care. The 2005 Medicare prosthetic device component prices were applied to current prosthetic and assistive-device use obtained from a national survey of 581 veterans and servicemembers with major traumatic amputations. Projections were made for 5-year, 10-year, 20-year, and lifetime costs based on eight Markov models. Average 5-year projected costs for prosthetic and assistive-device replacement for the Vietnam group are lower than for the OIF/OEF cohort due in part to use of fewer and less technologically a...
J Rehabil Res Dev
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September 2, 2010
Authors: Epstein RA, Heinemann AW, McFarland LV
The goals of rehabilitation after major limb loss include not only functional restoration but also a return to a high quality of life (QOL). Few studies have identified which factors are associated with QOL in veterans and servicemembers with combat-associated major limb loss. We enrolled Vietnam and Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) veterans and servicemembers in a national survey on prosthetic device use. In the Vietnam group, multivariate analysis found multiple limb loss (adjusted odds ratio [aOR] = 3.1, 95% confidence interval [CI] = 1.57-6.02) and satisfaction with current prostheses (aOR = 1.2, 95% CI = 1.05-1.38) are associated with better overall QOL, while a higher amputation impact rank (aOR = 0.66, 9...
J Rehabil Res Dev
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September 2, 2010
Authors: Berke GM, Fergason J, Milani JR, Hattingh J, McDowell M, Nguyen V, Reiber GE
Prosthetic care is a vital aspect of healthcare and rehabilitation for veterans and servicemembers with major traumatic limb loss. Our survey queried 581 veterans and servicemembers with limb loss from the Vietnam and Operation Iraqi Freedom (OIF)/Operation Enduring Freedom (OEF) conflicts. Among survey participants, 78.2% from the Vietnam conflict and 90.5% from the OIF/OEF conflict currently use prosthetic devices. In Vietnam respondents, 78% received prosthetic care from private sources, 16% from Department of Veterans Affairs (VA) prosthetic laboratories, 0.9% from Department of Defense (DOD), and 5% from multiple sources. In OIF/OEF respondents, 42% received prosthetic care from private sources, ...
J Rehabil Res Dev
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September 2, 2010
This article compares the Vietnam and the Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) groups with war-theater-associated multiple-limb loss to document significant changes in health status, prosthetic-device use, and long-term prognosis. During 2007 and 2008, a national survey queried 73 Vietnam veterans and 61 OIF/OEF servicemembers sustaining multiple-limb loss. Average years since limb loss are 39 for Vietnam veterans and 3 for OIF/OEF servicemembers. Self-rated health status was excellent or very good in 38.9% of the Vietnam group and 60.7% of the OIF/OEF group (p = 0.01). More of the OIF/OEF group than the Vietnam group reported performing high-impact aerobic activities, 18% versus 3% (p = 0.005). The OIF/OEF group currently uses more diverse prosthetic-device types t...
J Rehabil Res Dev
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September 2, 2010
Authors: Reiber GE, McFarland LV, Hubbard S, Maynard C, Blough DK, Gambel JM, Smith DG
Care of veterans and servicemembers with major traumatic limb loss from combat theaters is one of the highest priorities of the Department of Veteran Affairs. We achieved a 62% response rate in our Survey for Prosthetic Use from 298 Vietnam war veterans and 283 servicemembers/veterans from Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) who sustained major traumatic limb loss. Participants reported their combat injuries; health status; quality of life; and prosthetic device use, function, rejection, and satisfaction. Despite the serious injuries experienced, health status was rated excellent, very good, or good by 70.7% of Vietnam war and 85.5% of OIF/OEF survey participants. However, ma...
J Rehabil Res Dev
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September 2, 2010
Guest Editorial: Expert Panel recommendations-Based on research and deliberations from VA HSR&D project "Impact of the DOD paradigm shift on VA amputee prosthetic care"
J Rehabil Res Dev. 2010;47(4):xxix-xxxii
Authors: Reiber GE,
PMID: 20803398 [PubMed - as supplied by publisher] (Source: J Rehabil Res Dev)
J Rehabil Res Dev
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September 2, 2010
Authors: Sigford BJ
PMID: 20803396 [PubMed - in process] (Source: J Rehabil Res Dev)
J Rehabil Res Dev
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September 2, 2010
Authors: Pasquina PF
PMID: 20803395 [PubMed - in process] (Source: J Rehabil Res Dev)
J Rehabil Res Dev
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September 2, 2010
Authors: Reiber GE, Smith DG
PMID: 20803394 [PubMed - in process] (Source: J Rehabil Res Dev)
J Rehabil Res Dev
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September 2, 2010
Authors: John LT, Cherian B, Babu A
Falls are prevalent reasons for spinal cord injury (SCI). Postinjury fear of falling (FOF) can affect rehabilitation potential. We quantified FOF in 15 men with paraplegia (ambulatory with bilateral knee-ankle-foot orthoses [KAFOs] and elbow crutches) in correlation with their postural control at the center for long-term SCI rehabilitation of a tertiary-care teaching hospital. Our outcome measures comprised the American Spinal Injury Association Impairment Scale, the Modified Falls Efficacy Scale (MFES), postural sway measurements in the anteroposterior and mediolateral directions; and walking speed, cadence, and endurance. We assessed FOF with the MFES followed by measuring postural sway with a force platform. We measured gait parameters by asking t...
J Rehabil Res Dev
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September 2, 2010
Authors: Harada ND, Dhanani S, Elrod M, Hahn T, Kleinman L, Fang M
The aim of this study was to develop a system for and determine the feasibility of monitoring home exercise for physically inactive older adults using a Health Buddy (HB) text messaging device (Robert Bosch Healthcare; Palo Alto, California). Questions and messages related to exercise adherence are displayed on the HB screen and participants choose a response by pressing the corresponding button on the device. Responses are transmitted through a landline connection and high-risk responses are highlighted by the system for follow-up. We developed the questions and messages based on input from patient and clinician focus groups. We evaluated feasibility by administering the intervention to inpatient and outpatient adults ...
J Rehabil Res Dev
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September 2, 2010
Authors: Vogel WB, Barnett TE, Reker D
Within the Veterans Health Administration (VHA), the top tier of postacute rehabilitation care is provided in acute rehabilitation bedservice units (ARBUs). The next level of care is provided in subacute rehabilitation bedservice units (SRBUs). We fitted reduced-form and structural models to explain VHA cost differences between ARBUs and SRBUs across time and for the individual cost components. We included sociodemographic variables, time since stroke onset, care facility, and the Functional Independence Measure at admission as explanatory variables. The multivariable results indicate that total index stay costs are lower in ARBUs by almost $6,000 (or approximately 25%) compared with SRBUs. Moreover, the lower costs observed in ARBUs in this study...
J Rehabil Res Dev
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September 2, 2010
Authors: Wallin MT
PMID: 20803384 [PubMed - in process] (Source: J Rehabil Res Dev)
J Rehabil Res Dev
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September 2, 2010
Although the adverse health effects of nanoparticles/materials have been proposed and are being clarified, their facilitating effects on preexisting pathological conditions have not been fully examined. In this paper, we provide insights into the immunotoxicity of nanoparticles/materials as an aggravating factor in hypersusceptible subjects, especially those with immune-related respiratory disorders using our in vivo experimental model. We first exhibit the effects of nanoparticles/materials on lung inflammation induced by bacterial endotoxin (lipopolysaccharide: LPS) in vivo as a disease model in innate immunity, and demonstrated that nanoparticles instilled through both an intratracheal tube and an inhalation system can exacerbate the lung inflammation. Secondly, we introduce the effects...
Journal of Nanomaterials
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September 2, 2010
Abstract: The aim of this study was to evaluate the impact of different dimensions of obsessiveâcompulsive symptoms, of co-morbid anxious depressive symptoms, and of sociodemographic characteristics on the quality of life of patients with obsessiveâcompulsive disorder (OCD). We evaluated 53 patients with OCD and 53 age- and gender-matched individuals from the community with a sociodemographic questionnaire, the Structured Clinical Interview for the Diagnosis of Diagnostic and Statistical Manual of Mental Disorders, fourth Edition, (DSM-IV), the Short-Form Health Survey-36 (SF-36), the Saving InventoryâRevised, the ObsessiveâCompulsive InventoryâRevised, the Beck Depression Inventory and the Beck Anxiety Inventory. A series of stepwise linear regression analyses were performed, ha...
Psychiatry Research
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September 2, 2010
Abstract: Suicide is a leading cause of death in individuals 15â34years of age in China. Highly lethal pesticides are a common method used for suicide in Chinese rural areas. This case-control study aimed to test hypotheses concerning the suicide risks associated with pesticide access. Subjects included 370 rural completed suicides aged 15â34years and 370 living controls matched on age, gender and residence (rural/urban location). Data were collected by a psychological autopsy design with proxy respondents. Pesticide access was a significant risk factor for suicide even after controlling for other known risk factors in social and psychiatric domains, such as education level, living situation, marital status, family annual income and mental disorder. Increased risk was accounted for by ...
Psychiatry Research
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September 2, 2010
Abstract: Suicide is a public health problem all around the world. Family studies showed a strong heritability but, to date, few genetic data are available. Thus, in the present study we investigated whether a panel of single nucleotide polymorphisms (SNPs) in neuronal cell adhesion molecule 1 (NCAM) 1 was associated with suicidal behaviour as well as specific traits related to suicide. A total of two hundred and fifty-nine individuals with a positive history of suicidal behaviour and 312 healthy subjects were enrolled in the study. Rs2301228, rs1884, rs1245113, rs1369816, rs2196456 and rs584427 in NCAM1 were genotyped. No marker was significantly associated with suicidal behaviour vs. controls or with sub-types of attempted vs. completed, violent vs. non-violent, impulsive vs. non-impulsi...
Psychiatry Research
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September 2, 2010
Abstract: Excessive daytime sleepiness (EDS) is a symptom with high public health importance. Within psychiatric settings, depression is the most significant risk factor for EDS; however, this relationship has not been clearly detailed. The aim of this study was to describe the quality of sleep of depressed patients with and without EDS and to investigate the association between EDS and depression severity. A cross-sectional study with 78 female depressed outpatients (34.17±11.37years; range 18â60) was performed. The Epworth Sleepiness Scale, the Athens Insomnia Scale, the Pittsburgh Sleep Quality Index, and the Hamilton Rating Scale for Depression (HRSD) were administered. Patients were classified in two groups: with (43.5%) and without (56.5%) EDS. There were no differences with regar...
Psychiatry Research
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September 2, 2010
This study investigated whether an analysis of narrative style (word use and cross-clausal syntax) of patients with symptoms of generalised anxiety and depression disorders can help predict the likelihood of successful participation in guided self-help. Texts by 97 people who had made contact with a primary care mental health service were analysed. Outcome measures were completion of the guided self-help programme, and change in symptoms assessed by a standardised scale (CORE-OM). Regression analyses indicated that some aspects of participants' syntax helped to predict completion of the programme, and that aspects of syntax and word use helped to predict improvement of symptoms. Participants using non-finite complement clauses with above-average frequency were four times more likely to com...
Psychiatry Research
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September 2, 2010
A Westmoreland County senior living outfit is finding success curbing health care costs for employees through an intensive wellness program. (Source: bizjournals.com Health Care:Health Insurance headlines)
bizjournals.com Health Care:Health Insurance headlines
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August 22, 2010
Wellness programs donât have to be complicated to be successful. (Source: bizjournals.com Health Care:Health Insurance headlines)
bizjournals.com Health Care:Health Insurance headlines
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August 22, 2010
A Nashville company that designs and installs turnkey hospital rooms plans to use a new manufacturing facility under construction in Robertson County as a launch pad for international growth. (Source: bizjournals.com Health Care:Health Insurance headlines)
bizjournals.com Health Care:Health Insurance headlines
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August 22, 2010
A Westmoreland County senior living outfit is finding success curbing health care costs for employees through an intensive wellness program. (Source: bizjournals.com Health Care:Biotechnology headlines)
bizjournals.com Health Care:Biotechnology headlines
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August 22, 2010
Wellness programs donât have to be complicated to be successful. (Source: bizjournals.com Health Care:Biotechnology headlines)
bizjournals.com Health Care:Biotechnology headlines
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August 22, 2010
A Nashville company that designs and installs turnkey hospital rooms plans to use a new manufacturing facility under construction in Robertson County as a launch pad for international growth. (Source: bizjournals.com Health Care:Biotechnology headlines)
bizjournals.com Health Care:Biotechnology headlines
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August 22, 2010
Conclusions. A community-based aquatic exercise programme is feasible and resulted in improvement in motor functions of individuals with multiple sclerosis. These findings indicate that an aquatic training programme is appropriate and beneficial for individuals with multiple sclerosis and should be considered to augment the rehabilitation of those individuals. This programme may provide a viable model for a community-based wellness programme for people with disability including individuals with multiple sclerosis.
PMID: 20726740 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)
Disability and Rehabilitation
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August 19, 2010
The objective of this study was to determine if prolonged exercise resulted in the appearance of cardiac troponin T (cTnT)
in serum and whether this was associated with elevated levels of myocardial oxidative stress. Forty-five male SpragueâDawley
rats were randomized into four groups and killed before (PRE-EX), immediately (0HR), 2 (2HR) and 24 h (24HR) after a 3-h bout
of swimming with 5% body weight attached to their tail. In all animals serum cTnT was assayed using 3rd generation electrochemiluminescence.
In homogenized heart tissue myocardial malondialdehyde (MDA), a marker of lipid peroxidation, glutathione (GSH), and a non-enzymatic
estimate of total antioxidant capacity (T-AOC) were assessed spectrophotometrically. At PRE-EX cTnT was undetectable in all
animals. At 0HR...
European Journal of Applied Physiology
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August 13, 2010
CONCLUSIONS: Among depression and anxiety sufferers, CINA in relative isolation was associated with a significant negative impact on health care utilization and its associated costs, health-related quality of life, and work productivity.
PMID: 20694118 [PubMed - as supplied by publisher] (Source: Primary Care Companion to the Journal of Clinical Psychiatry)
Primary Care Companion to the Journal of Clinical Psychiatry
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August 12, 2010
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